Nitrazepam has long been affiliated with intense hepatic Ailments, much like other nitrobenzodiazepines. Nitrobenzodiazepines including nitrazepam, nimetazepam, flunitrazepam, and clonazepam are more harmful on the liver than other benzodiazepines as They can be metabolically activated by CYP3A4 which may lead to cytotoxicity.This generalized facts